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Pioneering multi-functional small molecules to combat  neurodegenerative diseases

Innovative chemistry platform to generate first-in-class small molecules modulating three known processes involved in neurodegeneration: protein misfolding, oxidative stress and neuro-inflammation

Our Trojan horse

Ilios is the ancient name of Troy. Our Trojan horse delivers multi-functional drugs to the brain. 

Multi-functional
small molecules

Modulating three known disease processes: protein mislocalization, oxidative stress and neuroinflammation

Rational-design merges validated components

Merging bioactive pharmacophores with glutathione and fatty acids to create brain-penetrant compounds that overcome limitations of individual components

Chemistry platform builds pipeline 

Innovative chemistry platform to address multiple neurodegenerative diseases

Novel approach 

A first in class multi-functional molecule to combat neurodegeneration

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Rationally designing multi-functional molecule
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Lead program in ALS

Pathophysiology-specific functional screens

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  • TDP-43 mislocalization​

  • Disregulated NRF-2 

  • Inflamed microglia

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Platform leverages bioactive pharmacophores to build pipeline
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Seeking collaborations to accelerate and expand our pipeline

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